Trouble always comes in threes: three mutations for three auto inflammatory genes in a child and in his father

Methods We report the clinical case of a 4 years old child who presented arthralgia since the age of 2,5 years. An orthopaedic diagnosed them as “growing pain”. Some months later he presented fever, neutrophilic leucocytosis, significant elevation of CRP and ESR associated to legs pain; he was treated with antibiotics and NSAID with a poor response. In the last year these episodes were monthly recurrent, associated with abdominal pain, oral aphtae, exanthema, conjunctivitis. The attacks are 3-4 sometimes 7 days long, have a monthly recurrence and do not show a seasonal prevalence. He showed a weight loss (weight: -2SDS; height: -1SDS); in the free intervals he was in wellbeing.